Signal transduction: Wnt signalling shows its versatility
نویسنده
چکیده
Signalling between cells plays a major role in the elaboration of cell types and tissues, triggering cell fate decisions that are critical in development. A number of pathways have been identified that appear time and again in different contexts. One good example is the pathway that first came to light with the identification of wingless mutant fruitflies. The Drosophila Wingless protein is now known to be the prototype of a family of signalling molecules that are more generally known as ‘Wnts’ — a hybrid of Wingless and Int-1, the related product of a mammalian oncogene. Much has been learned in recent years about Wingless/Wnt signalling, but new studies of the pathway in Drosophila and the nematode Caenorhabditis elegans show that the early picture of a linear signalling pathway was, perhaps not surprisingly, overly simplistic. New inputs and outputs have been discovered that help match the workings of the pathway to the specific requirements of the various different contexts in which it functions.
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ورودعنوان ژورنال:
- Current Biology
دوره 9 شماره
صفحات -
تاریخ انتشار 1999